Rb(Phospho Ser811) Polyclonal Antibody, 100ul Cell Separation and Collection This protein shares strong similarity

This protein shares strong similarity with DNA replication factor C (RFC)| and can form a complex with RFCs

Transiently dissociates following mitogenic stimulation

Multiple transcript variants encoding different isoforms have been found for CABLES1

BARD1 encodes a protein which interacts with the N-terminal region of BRCA1

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Rb(Phospho Ser811) Polyclonal Antibody, 100ul Cell Separation and Collection This protein shares strong similarityThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.