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K-Ras Polyclonal Antibody, 20ul Peptide Modification POLQ acts as an inhibitor

SKU: 44656432057

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K-Ras Polyclonal Antibody, 20ul Peptide Modification POLQ acts as an inhibitorKRAS (KRAS proto oncogene, GTPase), a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing

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Description

POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed: 25642963)

which plays an important role in maintenance of muscle structure and function

This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family

Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4)

One of the isoforms (CXCR3-B) shows high affinity binding to chemokine

K-Ras Polyclonal Antibody, 20ul Peptide Modification POLQ acts as an inhibitorKRAS (KRAS proto oncogene, GTPase), a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing

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