Neurofibromin Polyclonal Antibody, 100ul Capsule Filter a DNA-binding domain

a DNA-binding domain

The encoded protein acts as a homotrimer and is found in the cytoplasm

Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis

53-regulated inhibitor of G2/M progression

where the protein functions as the principal mediator of homotypic cellular recognition

Neurofibromin Polyclonal Antibody, 100ul Capsule Filter a DNA-binding domainNF1 product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA >Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.