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LIR-6 Polyclonal Antibody, 100ul[BT-AP05031] Inoculating Loops/Needles ZPBP is one of several

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LIR-6 Polyclonal Antibody, 100ul[BT-AP05031] Inoculating Loops/Needles ZPBP is one of severalLILRA1 encodes an activating member of the leukocyte immunoglobulin like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Description

ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix| the zona pellucida (McLeskey et al

Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2)

Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK)

The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains

thereby releasing the attached protein from the plasma membrane

LIR-6 Polyclonal Antibody, 100ul[BT-AP05031] Inoculating Loops/Needles ZPBP is one of severalLILRA1 encodes an activating member of the leukocyte immunoglobulin like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms.

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