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AGS3 Polyclonal Antibody, 20ul Protein Modification Elevate your workflow with tubesG protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G protein subunits. GPSM1 encodes a receptor independent activator of G protein signaling, which is one of several factors that influence the basal activity of G protein signaling systems. The G protein signaling modulator 1 contains seven tetratricopeptide repeats in its N terminal half and four G protein regulatory (GPR) motifs in its C terminal half.