Rb Polyclonal Antibody, 100ul[BT-AP07687] Recombinant Ab Production The protein encoded by this

The protein encoded by this gene is a member of the shugoshin family of proteins

which is essential for the catalytic activity

Alternative splicing of this gene results in two transcript variants encoding two different isoforms| one membrane-bound and one soluble

Transcriptional suppressor

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Rb Polyclonal Antibody, 100ul[BT-AP07687] Recombinant Ab Production The protein encoded by thisThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.