ASCC1 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Amplification ranging from neonatal adrenoleukodystrophy to

ranging from neonatal adrenoleukodystrophy to Zellweger syndrome

The NRGN gene contains four exons and three introns

Two transcript variants encoding different isoforms have been found for GNPAT

It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome

Alternative splicing results in multiple transcript variants| at least one of which encodes an isoform that is proteolytically processed

ASCC1 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Amplification ranging from neonatal adrenoleukodystrophy toThis gene encodes a subunit of the activating signal cointegrator 1 (ASC 1) complex. The ASC 1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP 1), nuclear factor kappa B (NF kB) and serum response factor (SRF). The encoded protein contains an N terminal KH type RNA binding motif which is required for AP 1 transactivation by the ASC 1