G Alpha i-3 Polyclonal Antibody, 50ul Cell Function Analysis The protein encoded by SMAD6

The protein encoded by SMAD6 belongs to the SMAD family of proteins

The protein encoded by this gene interacts with SH3 domain-containing proteins| binds mitotic arrest deficient 2 beta protein| and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

Two transcript variants encoding distinct isoforms have been identified for this gene

Binding to actin occurs through a C-terminal verprolin homology domain in all family members

The encoded preproprotein is proteolytically processed by furin to generate the mature receptor

G Alpha i-3 Polyclonal Antibody, 50ul Cell Function Analysis The protein encoded by SMAD6Guanine nucleotide binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. GNAI3 encodes an alpha subunit and belongs to the G alpha family. Mutation in this gene, resulting in a gly40 to arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein coupled endothelin receptor