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Critical Price Increases (December 2025 - March 2026): Ingredient Price Increase Primary Use Thiocolchicide 106% Muscle relaxant Glycerin 64% Solvent, excipient Nimesulide 53% Pain relief Deflazacort 50% Steroid Clobetasol Propionate 47% Skin treatment Amoxicillin Trihydrate 45% Antibiotic Paracetamol 26% Fever, pain Diclofenac Sodium 25-30% Anti-inflammatory Ciprofloxacin 20-30% Antibiotic Solvents (IPA, Acetone) 20-30% Manufacturing Multiple Factors Driving Crisis: Rupee depreciation against US dollar Petroleum-linked solvent costs (oil at $115/barrel) Container shortages and vessel delays from China Opportunistic pricing by some suppliers Industry Response: The Federation of Pharma Entrepreneurs has formally requested NPPA intervention, seeking permission for price hikes under DPCO 2013 Para 19

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Additionally, GABAergic signaling inhibits the cAMP/PKA pathway within neurons via GABAB receptors