ING5 Polyclonal Antibody, 50ul Enzyme Activity Assays Mutations in this gene are

Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome

POLR2E (RNA polymerase II subunit E) encodes the fifth largest subunit of RNA polymerase II

A pseudogene of this gene is found on chromosome X

Specific F-box proteins recognize different target protein(s)

Mg2+/Mn2+ dependent 1K

ING5 Polyclonal Antibody, 50ul Enzyme Activity Assays Mutations in this gene areThis gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants.