TRF1(Phospho Ser219) Polyclonal Antibody, 50ul Sampling Tubes Dimerization with other BHLH proteins

Dimerization with other BHLH proteins is required for efficient DNA binding

May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT

cell cycle progression and apoptosis

Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM)

Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance

TRF1(Phospho Ser219) Polyclonal Antibody, 50ul Sampling Tubes Dimerization with other BHLH proteinsThis gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C terminal Myb motif, a dimerization domain near its N terminus and an acidic N terminus. Two transcripts of this gene are alternatively