OPA1 Polyclonal Antibody, 50ul Diagnostic Probes & Oligos Recent reports show that this

Recent reports show that this protein is found both in the cytosol and the mitochondria

|Belongs to the peptidase S1 family

Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane

A mutation in this gene has been shown to result in polyhydramnios

Individual members of this family differ in the number of C-terminal TS motifs

OPA1 Polyclonal Antibody, 50ul Diagnostic Probes & Oligos Recent reports show that thisThis gene product is a nuclear encoded mitochondrial protein with similarity to dynamin related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.