HLA Class I Polyclonal Antibody, 100ul[BT-AP10061] Pipette Micro Tips The five genes share a

The five genes share a remarkably high degree of sequence identity

NBEAL2 (neurobeachin-like protein 2)

CHRNA1 encodes an alpha subunit that plays a role in acetlycholine binding/channel gating

CEBPB encodes a transcription factor that contains a basic leucine zipper (bZIP) domain

It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1

HLA Class I Polyclonal Antibody, 100ul[BT-AP10061] Pipette Micro Tips The five genes share aHLA A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon