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Musculoskeletal disorders, including tendinopathy, sarcopenia, osteoarthritis and osteoporosis, represent a major and growing global health burden, with osteoarthritis affecting 32.5 million adults in the United States, osteoporosis affecting 8.4-17.7% of middle-aged and elderly adults and nearly half of skeletal muscle mass being lost by the age of 80 years due to sarcopenia (1,2), particularly in aging populations (3)

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114 In contrast to the stimulation of ATP production by low H 2 S levels, higher H 2 S concentrations inhibit complex IV of the mETC and thereby impair ATP production

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