WNK4 Polyclonal Antibody, 100ul Cellular Cultivation & Health Management This motif is important for

This motif is important for interaction with SKP1 and for targeting some proteins for degradation

This gene is present in a gene cluster with other members of the ADAM family on chromosome 8

The protein encoded by this gene is similar to the chicken and mouse CRTAP genes

which is an essential step in neurogenesis

MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al

WNK4 Polyclonal Antibody, 100ul Cellular Cultivation & Health Management This motif is important forThis gene encodes a member of the WNK family of serine threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.