ErbB-3 Polyclonal Antibody, 50ul[BT-AP03041] Drug Development and Evaluation Knockout studies in mice suggest

Knockout studies in mice suggest that the different receptors

Overexpression of this gene may play a role in leukemogenesis| and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein

this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide

CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al

The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes

ErbB-3 Polyclonal Antibody, 50ul[BT-AP03041] Drug Development and Evaluation Knockout studies in mice suggestERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation