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MIB2 Polyclonal Antibody, 100ul Modification Enzymes This gene belongs to the

SKU: 15660307634

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MIB2 Polyclonal Antibody, 100ul Modification Enzymes This gene belongs to theE3 ubiquitin protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction: Down regulated in many primary skin melanomas. Treatment with a demethylating agent, 5' aza 2 deoxycytidine, restores expression, suggesting that down regulation is the result

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Description

This gene belongs to the guanine-binding protein (GBP) family

Participates in Wnt signaling (By similarity)

but differing in the UTRs

encoded by separate genes

Automatic Calibration: The DLAB pipette can be calibrated automatically by connecting it to a USB-enabled balance

MIB2 Polyclonal Antibody, 100ul Modification Enzymes This gene belongs to theE3 ubiquitin protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction: Down regulated in many primary skin melanomas. Treatment with a demethylating agent, 5' aza 2 deoxycytidine, restores expression, suggesting that down regulation is the result

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