Human Dickkopf-related Protein 4, DKK4 ELISA Kit, 96T Recombinant Ab Production PubMed: 17635946

PubMed: 17635946

Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18

Say goodbye to tedious mixing and hello to increased productivity with the PS1

May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots

and mutations in SLC25A12 may also be a cause of global cerebral hypomyelination

Human Dickkopf-related Protein 4, DKK4 ELISA Kit, 96T Recombinant Ab Production PubMed: 17635946Antagonizes canonical Wnt signaling by inhibiting LRP5 6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone