NPC1 Rabbit Polyclonal Antibody, 50ul Transporters The encoded protein| which functions

The encoded protein| which functions as a repressor| may play a role in brain development

involved in leukocyte transmigration

The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues

An important paralog of this gene is TNFAIP8L2

and the size of the purified protein

NPC1 Rabbit Polyclonal Antibody, 50ul Transporters The encoded protein| which functionsThis gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N terminal domain. It is predicted to have a cytoplasmic C terminus 13 transmembrane domains and 3 large loops in the lumen of the endosome the last loop being at the N terminus. This protein transports low density lipoproteins to late endosomal lysosomal compartments