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S12A1 Rabbit Polyclonal Antibody, 50ul Primary Antibodies This gene encodes a protein

SKU: 12811219985

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S12A1 Rabbit Polyclonal Antibody, 50ul Primary Antibodies This gene encodes a proteinThis gene encodes a kidney specific sodium potassium chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter like syndromes result from defects in this gene. Alternative splicing results

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Description

This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals

which suggests the tumor suppressor function of this gene

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats

originally purified from human erythrocytes

An alternatively spliced transcript variant of this gene has been reported| however| its full length nature is not known

S12A1 Rabbit Polyclonal Antibody, 50ul Primary Antibodies This gene encodes a proteinThis gene encodes a kidney specific sodium potassium chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter like syndromes result from defects in this gene. Alternative splicing results

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