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The anaerobic chamber was filled with a mixed gas composed of 5% H 2 , 5% CO 2 , and 90% N 2 provided by Airgas (Durham, NC, United States)

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Quick Answer: Tirzepatide causes constipation in 12-26% of patients by slowing gastrointestinal motility through GLP-1 receptor activation, which delays transit time and increases water reabsorption from the colon

This contributes to the broader evidence base for the medicine's safety profile and is an important part of how medicines are evaluated before licensing