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To date, NADPH metabolism has been targeted primarily for cancer therapeutics as cancer cells upregulate NADPH synthesis to support their massive antioxidative and anabolic requirements (55)

Recently, accumulating evidence has revealed that components of the ubiquitin proteasome system (UPS) participate in the posttranslational regulation of these proteins, suggesting that they might play a role in maintaining copper homeostasis

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In some cases, hepatocyte hypertrophy related to metabolic enzyme induction may not be evident to the pathologist when liver weight increase is small for a group, for example, less than 20%