AR-42 AC for CDK6 Halofuginone (0

Halofuginone (0

Trimmer JK

InChi: InChI=1S/C26H26N2O2/c1-30-26(29)25(16-22-17-27-24-15-9-8-14-23(22)24)28(18-20-10-4-2-5-11-20)19-21-12-6-3-7-13-21/h2-15

InChiKey: WMHAFZOOUBPQRX-SGXFGELCNA-N

17 1679 PMID: 17251021

AR-42 AC for CDK6 Halofuginone (0AR 42, also known as (S) HDAC 42; AR 42; NSC 736012; OSU 42; OSU HDAC 42; OSUHDAC 42, is a broad spectrum deacetylase inhibitor of both histone and non histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies when compared in preclinical studies to vorinostat (also known as "SAHA" or Zolinza), the first of two marketed compound in the class. AR 42 may possess additional histone independent