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Semaglutide has a longer safety track record

For readers who want a broader overview of side effect patterns, GLP-1 Side Effects in 2026: What Our Team Sees Every Day is a helpful companion article

Serious but Rare Side Effects Less common but more serious side effects can include: Pancreatitis Severe abdominal pain that requires immediate medical attention Gallbladder problems May cause pain in the upper right abdomen Severe gastroparesis Stomach paralysis that can be dangerous Kidney problems Changes in urination or swelling Severe allergic reactions Reported in less than 1% of patients Diabetic retinopathy In people with diabetes Possible risk of thyroid cancer Only seen in animal studies and not in humans Low blood sugar Particularly if taken with other diabetes medications like insulin These serious side effects occur in less than 1% of patients but require immediate medical evaluation if symptoms develop

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