MLH3 Polyclonal Antibody, 50ul Modified Oligos The protein functions as a

The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain

in which it interacts directly with SKP1

this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release

The encoded protein is a class 3 semaphorin receptor| and may be involved in cytoskeletal remodeling and as well as apoptosis

MLH3 Polyclonal Antibody, 50ul Modified Oligos The protein functions as aMLH3 is a member of the MutL homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The mutL homolog 3 encoded by MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis