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These oxysterols have also shown to induce HSP60 (Kim et al., 2024), which could further contribute to IL-1 production through the activation of the TLR4/p38 MAPK signaling axis (Swaroop et al., 2016)

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When it accumulates in patches, it can lead to dark spots

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[1] The FDA prescribing information does not specify a required washout period before conception, so women should consult with their healthcare provider about appropriate timing