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However, it is important to note that in our study, all patients who were taking valproic acid and carbamazepine were on polytherapy

Cystathionine synthase and cystathioninase require P5P as a cofactor, and the committed first step in the degradation of homocysteine, cystathionine synthase, also requires serine, a downstream metabolite of betaine (Figure 54-6)