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The difficulty in predicting therapeutic efficacy represents a significant impediment

AstraZeneca Advances #Oral #GLP-1 #Elecoglipron to #Phase #3 After Hitting Phase 2 Endpoints AstraZeneca confirmed that its oral GLP-1 candidate elecoglipron met primary endpoints in two Phase 2 trials and will now advance into Phase 3 while holding back detailed weight-loss data until June

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Given the benefits of tirzepatide on weight, waist circumference, and lipid parameters in addition to impressive improvements in glycaemic control, this medication appears to be ideally placed as first add-on therapy for individuals not at HbA1c target on metformin, particularly for those with T2D and excess adiposity (Table 2, clinical scenario A)

Maximum intensity projection images were compiled from z-stack optical sections for LAMP1 and ASGR1 staining