Allopurinol 835 3-d]pyrimidine-6-carboxamide

3-d]pyrimidine-6-carboxamide

More significant degradation of p-C-Raf and p-MEK1/2

Epub 2005 Dec 22

in combination with bortezomib in multiple myeloma

13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12

Allopurinol 835 3-d]pyrimidine-6-carboxamideAllopurinol is a structural isomer of hypoxanthine. Allopurinol inhibits the enzyme xanthine oxidase, which converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, which provvides protection against uric acid mediated end organ damage in conditions associated with excessive production of uric acid, i. e. the massive cell lysis associated with the treatment of some