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Regulation of circadian rhythms through pineal gland affecting melatonin production (melatonin has retinal protective properties)

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Wound healinga tightly coordinated cascade involving keratinocytes, macrophages, fibroblasts, and endothelial cellsrequires robust angiogenesis during the proliferative phase to establish a nutrient/oxygen supply via granulation tissue vascularization [12, 15]

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