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The activation of this GPCR by natural Glp-1 or synthetic Glp-1 analogs, such as exendin-4 or Liraglutide (6) increases intracellular Ca 2+ and activates adenylate cyclase to increase cyclic adenosine monophosphate (cAMP) levels and subsequent signaling pathways such as Protein kinase A (PKA) or Phosphoinositide 3-kinase (PI3K) (7)

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