Siah-2 Polyclonal Antibody, 100ul Yeast Expression The presence of a putative

The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins

mediating their interaction

Amplification and overexpression of this gene have been observed in several types of human carcinomas

It is also found to be expressed in lipogenic breast cancers| which suggests a role in controlling tumor lipid metabolism

Contains 5 WD repeats

Siah-2 Polyclonal Antibody, 100ul Yeast Expression The presence of a putativeSIAH2 encodes E3 ubiquitin protein ligase SIAH2 that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.