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Dose-proportional pharmacokinetics was observed following single dose intravenous administration of 2.5 to 10 g of hydroxocobalamin in healthy volunteers

Since vitamin B12 is water-soluble, any excess is naturally eliminated by the body, significantly lowering the risk of toxicity

Insurance companies evaluate whether oral or outpatient alternatives were attempted first, severity of the condition, and cost-effectiveness compared to inpatient hospital treatment

Some patients find that consuming protein shakes between meals, rather than with meals, works better when appetite is suppressed

There are also other delivery routes (intravenous, inhalation), but oral is the most accessible