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Prior to the proposal of the notion of ferroptosis, there have been multiple instances of abnormal buildup of iron in ischemic brain tissue (Kondo et al., 1995)

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Marqus-Torrejn MWC, Southgate B, Alfazema N, Clements MP, Garcia-Diaz C, Blin C, Arranz-Emparan N, Fraser J, Gammoh N, Parrinello S, Pollard SM (2021) LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells