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(2023) GLP-1 receptor agonists for the treatment of obesity: Role as a promising approach, Frontiers in endocrinology

With increasing serine levels, serine functions as an allosteric activator of PKM2, supporting aerobic glycolysis and regulating either pyruvate conversion to lactic acid or pyruvate catabolism into the tricarboxylic acid (TCA) cycle [22, 23]