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Sales of the therapy reached about $36.5 billion in 2025 , surpassing semaglutide and positioning it as one of the world's top-selling pharmaceuticals

Dihexa is studied in research models involving hepatocyte growth factor pathway activity, synaptogenesis, neuroplasticity-associated mechanisms, memory-related biology, and central nervous system signaling

The researchers found that the estimated mean change in hemoglobin A1c (HbA1c) after 40 weeks was 1.8, 1.5, and 0.1 percentage points for cagrilintide-semaglutide 2.4 mg each, 1.0 mg each, and placebo, respectively

Cagrilintide can be used in combination with any of the GLP-1 medications listed above

It is important to discuss the expectations for your specific situation with your surgeon pre-operatively