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CDK4 was found to carry SNPs associated with IGF-I response in both GHD and TS (Figure 4)

doi: 10.1097/01.tp.0000269199.16209.22 43 von BubnoffDWilmsHSchelerMBrenkMKochSBieberT

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The use of growth factors, both in animal models and in clinical trials, has shown promising effects in protecting dopaminergic neurons and astrocytes in damaged regions by the activation of different signaling pathways important in neuronal survival and regeneration