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MB can cause a rise in blood pressure and peripheral vascular resistance, and it may reduce regional blood flow (for instance, caution is needed in patients with pulmonary hypertension or compromised circulation because MB could potentially worsen those by opposing NO-mediated vasodilation)

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Two clusters (Cluster 5 and 8) of hepatic stellate cells were identified by IGFBP7, PDGFRA, COL3A1 and DCN markers

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The research also demonstrated that combinatory treatment with valproic acid further enhanced results, establishing the synergistic protocol that would become the standard approach

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Manjot Nagyal , Virginia Espina, Masoumeh Sikaroodi, and Patrick Gillevet

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