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doi: 10.1210/jc.2012-3855 33 RonnJJensenEPWewer AlbrechtsenNJHolstJJSorensenCM

10.1371/journal.pone.0035008 154

doi: 10.1146/annurev-cellbio-101512-122326

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Non-canonical pathways (including PI3K/AKT and Ras/MAPK signaling) also contribute to the cellular actions of prolactin ( The binding of prolactin to the long form of PRLR triggers a cascade of tyrosine kinase-dependent signaling events, including JAK2 autophosphorylation and subsequent phosphorylation of specific tyrosine residues on the receptor cytoplasmic domain ( STAT5A and STAT5B are highly conserved homologous transcription factors with amino acid sequences that contain six structurally and functionally distinct domains: an N-terminal domain, coiled-coil domain, DNA-binding domain, linker domain, SH2 domain, and C-terminal transactivation domain