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Activated IRS-1 recruits and activates phosphoinositide 3-kinase (PI3K), resulting in phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane

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Higher levels of oxidative stress (distress) are required in phagocytosis and thyroid hormone synthesis

However, the inclusion of subjective determinations is a disadvantage of the aforementioned semiquantitative scoring system