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Individual variability in response to incretin-based therapies is common and may reflect differences in underlying pathophysiology

These tips come from clinical guidance, nursing best practices, and the collective experience of thousands of self-injectors

Sulfonylureas also frequently need reduction or discontinuation

If you do decide to come off tirzepatide, a slow taper, regular check-ins, and maintaining healthy habits around food, movement, sleep, and stress all work together to help your body adjust