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The intrinsic factor-mediated pathway operates regardless of food presence, and the passive diffusion mechanism (responsible for absorbing about 1% of high doses) similarly functions independently of meals

These effects appear to arise indirectly through vascular support, inflammation control, and cellular protection rather than direct neurotransmitter stimulation

However, comparative research has been dominated by centring of western paradigms, implicitly positioning other cultures as peripheral or derivative

You can learn more in our guide on how to check for a vitamin deficiency

These alterations reduce systemic inflammation, promote immune tolerance, and decrease autoimmune attacks, thereby contributing to the relief of SSc symptoms