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The most commonly reported adverse reactions in clinical trials were gastrointestinal: nausea (up to 18 to 24% of users), diarrhea (up to 17%), vomiting, constipation, decreased appetite, dyspepsia, and abdominal pain

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These AEs are a well-known class effect of incretin-based therapies, stemming from their mechanism of action, particularly the delay in gastric emptying

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While some of this variation in results is likely attributable to the inherent variability of results between trials, some variation may be attributable to the slight differences in the patient populations between trials, where patients receiving tirzepatide in SURMOUNT-5 had a higher average waist circumference and body weight at baseline (mean [standard deviation (SD)] waist circumference 117.7 [16.1]

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Understanding normal appearance versus problematic changes helps ensure medication safety and therapeutic effectiveness

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