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A fluorescence activated cell sorter (FACS) analysis was performed using annexin V, which specifically and strongly binds to cell surface PI in order to confirm whether apoptotic or necrotic cell death was observed [30]

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Because IGFBP-3 also carries IGF-1, when IGF-1 is administered on its own, the carrier IGFBP-3 saturates with IGF-1 displacing IGF-2 and thus augments its free circulating concentration

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